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Chemical Structure : TGX-221
CAS No.: 663619-89-4
Catalog No.: PC-42325Not For Human Use, Lab Use Only.
TGX-221 is a potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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TGX-221 is a potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
TGX-221 weakly inhibits p110δ (IC50=211 nM), and no activity against p110α (IC50>1 uM).
TGX-221 inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding。
TGX-221 shows anti-thrombotic effectt devoid of other cardiovascular actions in rats.
| M.Wt | 364.4409 | |
| Formula | C21H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4H-Pyrido[1,2-a]pyrimidin-4-one, 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]- |
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1. Frazzetto M, et al. Biochem J. 2008 Sep 15;414(3):383-90.
2. Sturgeon SA, et al. Eur J Pharmacol. 2008 Jun 10;587(1-3):209-15.
3. Chaussade C, et al. Biochem J. 2007 Jun 15;404(3):449-58.
4. Straub A, et al. Thromb Haemost. 2008 Mar;99(3):609-15.
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