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TH-237A

Chemical Structure : TH-237A

CAS No.: 935467-97-3

TH-237A (TH 237A;TH237A;meso-GS 164)

Catalog No.: PC-42798Not For Human Use, Lab Use Only.

A novel, brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity.

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Biological Activity

A novel, brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity; increases neuronal survival in the presence of the Aβ peptides in rat isolated neuronal culture with EC50 of 5 nM.

Physicochemical Properties

M.Wt 333.3293
Formula C18H17F2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 46 mg/mL

Chemical Name/SMILES

1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)-rel-

References

1. Kelly E. Desino. Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects.

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