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Chemical Structure : TH-257
CAS No.: 2244678-29-1
Catalog No.: PC-35851Not For Human Use, Lab Use Only.
TH-257 (TH257) is a potent, selective, allosteric inhibitor of LIMK1 and LIMK2 with IC50 of 84 nM for LIMK1 and 39 nM for LIMK2 in a RapidFire MS assay.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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TH-257 (TH257) is a potent, selective, allosteric inhibitor of LIMK1 and LIMK2 with IC50 of 84 nM for LIMK1 and 39 nM for LIMK2 in a RapidFire MS assay.
TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 uM.
TH-257 displays IC50 of 250 nM against ectopically expressed full-length LIMK1 and 150 nM LIMK2 in a life cell NanoBRET assay.
| M.Wt | 422.543 | |
| Formula | C24H26N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide |
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1. Manetti F. et al. Eur J Med Chem. 2018 Jul 15;155:445-458.
2. Collins R, et, al. J Med Chem. 2022 Oct 27;65(20):13705-13713.
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