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Chemical Structure : TH-287
CAS No.: 1609960-30-6
Catalog No.: PC-45104Not For Human Use, Lab Use Only.
TH-287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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TH-287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM.
TH-287 shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity.
TH-287 causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
| M.Wt | 269.1299 | |
| Formula | C11H10Cl2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 2.6 mg/mL |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl- |
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1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Kawamura T, et al. Sci Rep. 2016 May 23;6:26521.
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