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TH1834 dihydrochloride

Chemical Structure : TH1834 dihydrochloride

CAS No.: 2108830-09-5

TH1834 dihydrochloride (TH-1834;TH 1834)

Catalog No.: PC-60499Not For Human Use, Lab Use Only.

TH1834 dihydrochloride (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor.

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    Biological Activity

    TH1834 dihydrochloride (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor.
    TH1834 induces apoptosis in breast cancer cell lines with more cytotoxicity than staurosporine.
    TH1834 increases the γH2AX foci in the cancer cell lines PC-3 and DU-145 combined with IR.
    TH1834 induces apoptosis and increases unrepaired DNA damage in breast cancer cells.

    Physicochemical Properties

    M.Wt 641.638
    Formula C33H42Cl2N6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(5-(4-((phenethyl(4-(4-(pyrrolidin-1-ylmethyl)phenoxy)butyl)amino)methyl)phenyl)-2H-tetrazol-2-yl)acetic acid dihydrochloride

    References

    1. Gao C, et al. Sci Rep. 2014 Jun 20;4:5372.

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