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THI0019

Chemical Structure : THI0019

CAS No.: 1378532-99-0

THI0019 (THI-0019, THI 0019)

Catalog No.: PC-38812Not For Human Use, Lab Use Only.

THI0019 is a small molecule agonist of the integrin α4β1 (very late antigen-4 or VLA-4) with EC50 of 1.7 uM in cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA.

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Biological Activity

THI0019 is a small molecule agonist of the integrin α4β1 (very late antigen-4 or VLA-4) with EC50 of 1.7 uM in cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA.
THI0019 enhances α4β7, α5β1, and αLβ2-mediated cell adhesion.
THI0019 does not induce expression of α4β1 or LIBS epitopes.
THI0019 facilitates cell spreading on VCAM-1, and enhances SDF-1-mediated cell migration.

Physicochemical Properties

M.Wt 601.733
Formula C29H35N3O7S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl (6S,10S)-10-(benzo[d][1,3]dioxol-5-yl)-6-butyl-3,8-dioxo-1-(thiophen-2-yl)-2-(thiophen-2-ylmethyl)-4-oxa-2,7,9-triazadodecan-12-oate

References

1. Peter Vanderslice, et al. J Biol Chem. 2013 Jul 5;288(27):19414-28.

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