Chemical Structure : TJ-M11
CAS No.:
TJ-M11
Catalog No.: PC-24521Not For Human Use, Lab Use Only.
TJ-M11 is a synthesized peptide inhibitor of YAP/TAZ transactivation domain (TAD), specifically blocks YAP transactivation (IC50=5.96 uM, NCI-H1299 cells) by disrupting its TAD interactions with the cofactors MED15 and TAF4.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TJ-M11 is a synthesized peptide inhibitor of YAP/TAZ transactivation domain (TAD), specifically blocks YAP transactivation (IC50=5.96 uM, NCI-H1299 cells) by disrupting its TAD interactions with the cofactors MED15 and TAF4.
TJ-M11 blocks the interactions of YAP with TAF4 and MED15 in cells through Co-immunoprecipitation.
TJ-M11 disrupts the transcription of YAP target genes, including the immunosuppressive genes CSF1, ITGB2, and IL33.
TJ-M11 exhibits biological activity against cancer cell growth, inhibits primary patient-derived lung adenocarcinoma (LUAD) cells (LUAD1, IC50=6.77 uM).
TJ-M11 treatment significantly suppressed the tumor size, reverses adaptive resistance of anti-PD-1 inhibitor in TDCL tumor-bearing C57BL/6 mice.
Physicochemical Properties
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M.Wt
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2204.79
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Formula
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C112H174N26O20
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Sequence: Phe-Leu-Thr-Trp-Leu-Pro-Lys-Lys-Lys-Arg-Lys-Val-Phe-Leu-Thr-Trp-Leu
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References
1. Man Yu, et al. Nat Commun. 2025 Apr 24;16(1):3855.
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