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Chemical Structure : TKB245
Catalog No.: PC-49864Not For Human Use, Lab Use Only.
TKB245 (TKB-245) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.03 and 0.53 µM, respectively.
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TKB245 (TKB-245) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.03 and 0.53 µM, respectively.
TKB245 does not inhibits human cysteine enzymes, cathepsin L and calpain.
TKB245 demonstrates comparably active against a variety of SARS-CoV-2 variants including alpha, beta, gamma, delta, kappa, and omicron species (EC50=14-56 nM).
TKB245 exerts potent activity against SARS-CoV-2TWK521 with EC50 values of 0.021 and 0.0027 µM, respectively in HeLa-ACE2-TMPRSS2 and A549-ACE2-TMPRSS2 cells.
TKB245 exhibits significantly more potent activity than the two existing anti-SARS-CoV-2 drugs: molnupiravir and nirmatrelvir.
| M.Wt | 653.69 | |
| Formula | C30H35F4N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Higashi-Kuwata N, et al. Nat Commun. 2023 Feb 25;14(1):1076.
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