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Chemical Structure : TL-895
CAS No.: 1415823-49-2
Catalog No.: PC-21379Not For Human Use, Lab Use Only.
TL-895 (M7583) is a potent, highly selective, ATP-competitive, second-generation, irreversible inhibitor of Bruton's tyrosine kinase (BTK) with biochemical IC50 of 1.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $568 | In stock | |
| 100 mg | Get quote |
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TL-895 (M7583) is a potent, highly selective, ATP-competitive, second-generation, irreversible inhibitor of Bruton's tyrosine kinase (BTK) with biochemical IC50 of 1.5 nM.
TL-895 (M7583) has an average IC50 of 18.5 nM for BTK against Millipore Kinase Profiler screening panel, profiling across 270 protein kinases at 1 μM, only 3 additional kinases are also inhibited by TL-895 (Blk, BMX, and Txk) with IC50 values of 77, 5, and 62 nM, respectively.
TL-895 (M7583) inhibits BTK auto-phosphorylation at Y223 after BCR stimulation with anti-IgM in the human Burkitt's lymphoma B-cell line Ramos with IC50 of 1-10 nM.
TL-895 (M7583) inhibits growth of primary CLL blasts in vitro with IC50 of 0.2 uM, similar to ibrutinib and acalabrutinib.
TL-895 (M7583) inhibits the ADCC mechanism of therapeutic antibodies only at supra-clinical exposure levels.
TL-895 (M7583) significantly inhibits tumor growth in the Mino MCL xenograft model and in 5/21 DLBCL PDX models relative to vehicle controls.
| M.Wt | 447.51 | |
| Formula | C25H26FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-fluoropiperidin-1-yl)prop-2-en-1-one |
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1. Goodstal SM, et al. Sci Rep. 2023 Nov 21;13(1):20412.
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