Chemical Structure : TLR4-IN-C34
CAS No.: 40592-88-9
Catalog No.: PC-26584Not For Human Use, Lab Use Only.
TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
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|---|---|---|---|
| 5 mg | $58 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $128 | In stock | |
| 100 mg | Get quote |
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TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
| M.Wt | 389.40 | |
| Formula | C17H27NO9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2R,3S,4R,5R,6S)-5-Acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate |
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1. Wipf P, et al. Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.
2. Neal MD, et al. PLoS One. 2013 Jun 12;8(6):e65779.

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