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TLR4-IN-C34

Chemical Structure : TLR4-IN-C34

CAS No.: 40592-88-9

TLR4-IN-C34

Catalog No.: PC-26584Not For Human Use, Lab Use Only.

TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.

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Biological Activity

TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.

Physicochemical Properties

M.Wt 389.40
Formula C17H27NO9
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3S,4R,5R,6S)-5-Acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate

References

1. Wipf P, et al. Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.

2. Neal MD, et al. PLoS One. 2013 Jun 12;8(6):e65779.

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