TLR 7/8 agonist 558 | TLR7/8 agonist | Probechem Biochemicals

Chemical Structure : TLR 7/8 agonist 558

TLR 7/8 agonist 558 (TLR7/8 agonist 6)

Catalog No.: PC-25312Not For Human Use, Lab Use Only.

TLR 7/8 agonist 558 (TLR7/8 agonist 6) is a potent TLR7 and TLR8 small molecule agonist with EC50 of 0.18 uM and 5.34 uM respectively, stimulates TNFα, IFNγ, and IL-1β.

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Biological Activity

TLR 7/8 agonist 558 (TLR7/8 agonist 6) is a potent TLR7 and TLR8 small molecule agonist with EC50 of 0.18 uM and 5.34 uM respectively, stimulates TNFα, IFNγ, and IL-1β.

Physicochemical Properties

M.Wt	417.51
Formula	C24H27N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinoline-7-carboxylate

References

1. Bhatnagar S, et al. J Immunother. 2025 Aug 6. doi: 10.1097/CJI.0000000000000571.

2. Yang M, et al. Bioorg Med Chem Lett. 2022;59:128548.

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TLR 7/8 agonist 558 (TLR7/8 agonist 6)

Biological Activity

Physicochemical Properties

References

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