TLR7/8 antagonist 1

Chemical Structure : TLR7/8 antagonist 1

Catalog No.: PC-25313Not For Human Use, Lab Use Only.

TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β.

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Biological Activity

TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β.

Physicochemical Properties

M.Wt	417.51
Formula	C24H27N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-amino-1-(4-(aminomethyl)benzyl)-2-isobutyl-1H-imidazo[4,5-c]quinoline-7-carboxylate

References

1. Yang M, et al. Bioorg Med Chem Lett. 2022;59:128548.

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