TLR9 antagonist 38

Chemical Structure : TLR9 antagonist 38

Catalog No.: PC-25546Not For Human Use, Lab Use Only.

TLR9 antagonist 38 is a highly potent, selective TLR9 antagonist with IC50 of 0.1 nM (hTLR9), >10,000-fold selectivity over hTLR2/4/5/7/8.

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Biological Activity

TLR9 antagonist 38 is a highly potent, selective TLR9 antagonist with IC50 of 0.1 nM (hTLR9), >10,000-fold selectivity over hTLR2/4/5/7/8.

M.Wt	455.61
Formula	C28H33N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-(4-((2-methoxybenzyl)amino)butyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)quinoline-8-carbonitrile

1. Xue Song, et al. ACS Med Chem Lett. 2025 Aug 26;16(9):1747-1755.