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Chemical Structure : TM-N1324
CAS No.: 1144477-35-9
Catalog No.: PC-38251Not For Human Use, Lab Use Only.
GPR39 agonist Cpd1324 (TM-N1324) is a potent, selective, orally active GPR39 agonist, activats human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.
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| 25 mg | $328 | In stock | |
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GPR39 agonist Cpd1324 (TM-N1324) is a potent, selective, orally active GPR39 agonist, activats human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.
GPR39 agonist Cpd1324 (TM-N1324) shows clean off-target activities using a panel of 165 GPCRs, i.e., the Millipore GPCR-profiler service, and has similar potencies on murine GPR39 (180 nM and 5 nM, in the absence and presence of Zn2+).
GPR39 agonist Cpd1324 increased GLP-1 secretion in the mice as well as in mouse and human intestinal organoids, but not in GPR39 KO mouse organoids.
| M.Wt | 397.798 | |
| Formula | C18H13ClFN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(2-chloro-4-fluorophenyl)-3-methyl-1-(9H-purin-6-yl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one |
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1. Grunddal KV, et al. Mol Metab. 2021 Jul;49:101207.
2. Thomas M Frimurer, et al. J Med Chem. 2017 Feb 9;60(3):886-898.
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