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Chemical Structure : TMP778
CAS No.: 1422171-08-1
Catalog No.: PC-60454Not For Human Use, Lab Use Only.
TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity.
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|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $448 | In stock | |
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| 100 mg | Get quote |
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TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity.
TMP778 blocks human Th17 and Tc17 cell differentiation and also acutely modulates IL-17A production and inflammatory Th17-signature gene expression (IL17a, IL17f, IL22, IL26, CCR6, and IL23) in mature human Th17 effector/memory T cells.
TMP778 inhibits IL-17A production in both human and mouse γδ T cells, also inhibits IL-23-induced IL-17A production.
TMP778 attenuates IMQ-induced skin inflammation in vivo.
| M.Wt | 494.591 | |
| Formula | C31H30N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-((3,5-dimethylisoxazol-4-yl)(hydroxy)methyl)benzofuran-5-yl)-N-((S)-(2,4-dimethylphenyl)(phenyl)methyl)acetamide |
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1. Skepner J, et al. J Immunol. 2014 Mar 15;192(6):2564-75.
2. Xiao S, et al. Immunity. 2014 Apr 17;40(4):477-89.
3. Skepner J, et al. Immunology. 2015 Jul;145(3):347-56.
4. Forcade E, et al. JCI Insight. 2017 Jun 15;2(12). pii: 92111.
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