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TNKS-IN-41

Chemical Structure : TNKS-IN-41

CAS No.: 1584646-59-2

TNKS-IN-41 (Tankyrase inhibitor 41)

Catalog No.: PC-60367Not For Human Use, Lab Use Only.

A highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively; shows high selectivity over the other PARP family members; induces growth inhibition of a number of tumor derived cell lines.

Physicochemical Properties

M.Wt 482.508
Formula C24H22N10O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO

Chemical Name/SMILES

(1-Methyl-1H-pyrazol-3-yl)(4-(4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzoyl)piperazin-1-yl)methanone

References

1. Thomson DW, et al. J Med Chem. 2017 Jul 13;60(13):5455-5471.

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