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Chemical Structure : TOP-N53
Catalog No.: PC-47068Not For Human Use, Lab Use Only.
TOP-N53 is a dual-acting nitric oxide (NO) donor and selective PDE5 inhibitor, potently inhibits PDE5 with IC50 of 1.6 nM.
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TOP-N53 is a dual-acting nitric oxide (NO) donor and selective PDE5 inhibitor, potently inhibits PDE5 with IC50 of 1.6 nM.
TOP-N53 increased the levels of cGMP in a concentration-dependent and time-dependent manner and was significantly more potent than sildenafil in treated human platelets.
TOP-N53 had no toxic effects on primary mouse fibroblasts and KCs, human blood endothelial cells (BECs), and human HaCaT KCs.
TOP-N53 promotes different parameters of wound healing in healthy mice, does not promote scarring.
TOP-N53 (0.2 nmol per injection day) promotes wound re-epithelialization and angiogenesis in mice with diabetes, directly induces healing-promoting activities in KCs and fibroblasts.
TOP-N53 promotes endothelial cell migration and tube formation in primary human BEC.
| M.Wt | 604.679 | |
| Formula | C27H36N6O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martínez-Martínez E, et al. Int J Mol Sci. 2022 Jun 20;23(12):6860.
2. Ben-Yehuda Greenwald M, et al. J Invest Dermatol. 2021 Feb;141(2):415-426.
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