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Chemical Structure : TP0541640
Catalog No.: PC-21122Not For Human Use, Lab Use Only.
TP0541640 (TP 0541640) is a novel potent LPA1 antagonist with IC50 of 1.6 nM, shows potential for the treatment of lung and skin fibrosis.
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TP0541640 (TP 0541640) is a novel potent LPA1 antagonist with IC50 of 1.6 nM, shows potential for the treatment of lung and skin fibrosis.
TP0541640 (10, 30, or 100 mg/kg) suppressed LPA-induced histamine release in C57BL6 mice.
TP0541640 shows anti-fibrotic effects suppressive effect in mouse model of bleomycin-induced skin fibrosis.
| M.Wt | 504.57 | |
| Formula | C27H34F2N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yuki Kobayashi, et al. Eur J Med Chem. 2023 Aug 20;260:115749.
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