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Chemical Structure : TP0628103
Catalog No.: PC-21674Not For Human Use, Lab Use Only.
TP0628103 is a highly potent, selective matrix metalloproteinase-7 (MMP-7) inhibitor with IC50 of 0.17 nM and 4.1 nM for human and mouse MMP-7, respectively.
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TP0628103 is a highly potent, selective matrix metalloproteinase-7 (MMP-7) inhibitor with IC50 of 0.17 nM and 4.1 nM for human and mouse MMP-7, respectively.
TP0628103 exhibits 15,000-fold, 4300-fold, and 10,000-fold selectivity for MMP-7 over MMP-2, MMP-12, and MMP-14, respectively.
TP0628103 also displays excellent (>59,000-fold) selectivity against MMP-1, -3, -8, -9, and -13 and low OATP-mediated hepatic uptake ratios (OATP1B1:1.20, OATP1B3:2.08).
TP0628103 (0.3 mg/kg/day) reduced renal collagen and caused significant inhibition of collagen production in mouse model of UUO-induced renal fibrosis.
| M.Wt | 1134.67 | |
| Formula | C51H67ClF3N11O11S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yusuke Oka, et al. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c01967.
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