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Chemical Structure : TPN729
CAS No.: 936951-20-1
Catalog No.: PC-63028Not For Human Use, Lab Use Only.
TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TPN729 (TPN-729) is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.
TPN729 selectively inhibits PDE5 and blocks the degradation of cyclic guanosine monophosphate, and is a promising PDE5 inhibitor providing fewer side effects and better compliance.
| M.Wt | 516.661 | |
| Formula | C25H36N6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-methyl-4-propoxy-N-[2-(1-pyrrolidinyl)ethyl]benzenesulfonamide |
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1. Wang Z, et al. J Sex Med. 2013 Nov;10(11):2790-7.
2. Zhu Y, et al. J Pharm Biomed Anal. 2016 Jan 5;117:217-26.
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