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Chemical Structure : TPP-IOA
Catalog No.: PC-21418Not For Human Use, Lab Use Only.
TPP-IOA is a specific inhibitor of cytochrome c (cyt c) peroxidase activity, inhibits peroxidase activity of cardiolipin-induced cytochrome c peroxidase activity with IC50 of 5 uM.
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TPP-IOA is a specific inhibitor of cytochrome c (cyt c) peroxidase activity, inhibits peroxidase activity of cardiolipin-induced cytochrome c peroxidase activity with IC50 of 5 uM.
TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol.
TPP-IOA dose-dependently inhibits the rate of resorufin formation of the cytochrome c/cardiolipin solution.
TPP-IOA is a specific mitochondria-targeted anti-peroxidase agent inhibiting mono-lyso-CL (MLCL)-cyt c peroxidase activity.
TPP-IOA (5 uM) significantly suppresses resorufin formation in isolated mitochondria.
TPP-IOA prevents phospholipid peroxidation, improves mitochondrial respiration of TAZ-deficient C2C12 myoblasts and restores exercise endurance in a Barth syndrome (BTHS) Drosophila model.
| M.Wt | 731.80 | |
| Formula | C42H56BrN2O2P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lucas A Maddalena, et al. Biochim Biophys Acta Bioenerg. 2017 Jan;1858(1):73-85.
2. Kagan VE, et al. Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome. Nat Metab. 2023 Nov 23. doi: 10.1038/s42255-023-00926-4.
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