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Chemical Structure : TPPB
CAS No.: 497259-23-1
Catalog No.: PC-38022Not For Human Use, Lab Use Only.
TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM.
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|---|---|---|---|
| 5 mg | $488 | In stock | |
| 10 mg | $798 | In stock | |
| 25 mg | $1280 | In stock | |
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| 200 mg | Get quote | ||
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TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM.
TPPB induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells.
TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.
| M.Wt | 501.54 | |
| Formula | C27H30F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2E,4E)-N-((2S,5S)-5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide |
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1. Alan P Kozikowski, et al. J Med Chem. 2003 Jan 30;46(3):364-73.
2. Yang HQ, et al. Eur J Neurosci. 2007 Jul;26(2):381-91.
3. Yi P, et al. J Mol Neurosci. 2012 Sep;48(1):234-44.
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