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Chemical Structure : TR120
Catalog No.: PC-20633Not For Human Use, Lab Use Only.
TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
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TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
TR120 is a potent inductor of apoptosis in the BCR-ABL-positive K562 and KCL-22 cell lines and in their imatinib resistant counterpart K562-R and KCL22-R cells in vitro.
TR120 induces a marked decrease in signal transducer and activator of transcription 5 (STAT5) expression in K562 cells.
TR120 exhibits synergistic effects when used in combination with imatinib in both sensitive and resistant cells.
| M.Wt | 525.30 | |
| Formula | C21H20INO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Romagnoli R, et al. Eur J Med Chem. 2016 Jan 27;108:39-52.
2. Grimaudo S, et al. Anticancer Drugs. 2013 Apr;24(4):384-93.
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