TREX1-IN-4

Chemical Structure : TREX1-IN-4

Catalog No.: PC-26960Not For Human Use, Lab Use Only.

TREX1-IN-4 (Compound 96) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM.

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Biological Activity

TREX1-IN-4 (Compound 96) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM.

M.Wt	490.90
Formula	C24H19ClN6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(((2-chlorophenyl)(3-cyanophenyl)methyl)(methyl)amino)-5-hydroxy-N-(isoxazol-4-yl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

1. Patent WO2021016317 A1, Pyrimidinediones as modulators of TREX1 and their preparation. Compound 96.