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Chemical Structure : TRO 40303
Catalog No.: PC-62133Not For Human Use, Lab Use Only.
TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM).
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TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM); has no effect on the calcium retention capacity (CRC) of isolated mitochondria; causes significant reduction in reactive oxygen species production and subsequent calcium overload; reduces infarct size when administered before reperfusion in in vivo model.
| M.Wt | 405.667 | |
| Formula | C26H47NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schaller S, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706.
2. Le Lamer S, et al. J Transl Med. 2014 Feb 7;12:38.
3. Hansson MJ, et al. Eur J Pharmacol. 2015 Aug 5;760:7-19.
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