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TRPM4 inhibitor 5

Chemical Structure : TRPM4 inhibitor 5

CAS No.: 351424-20-9

TRPM4 inhibitor 5 (TMEM206 inhibitor CBA)

Catalog No.: PC-35234Not For Human Use, Lab Use Only.

TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx), also inhibits TMEM206 with IC50 of 9.55 uM.

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Biological Activity

TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx), also inhibits TMEM206 with IC50 of 9.55 uM.
TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6.
TRPM4 inhibitor 5 (TMEM206 inhibitor CBA)demonstrates effective and specific inhibition of TMEM206.

Physicochemical Properties

M.Wt 340.156
Formula C15H11Cl2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid

References

1. Ozhathil LC, et al. Br J Pharmacol. 2018 Jun;175(12):2504-2519.
2. Sven Kappel, et al. Front Pharmacol. 2024 Mar 7:15:1369513.

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