TRPM4 inhibitor PBA

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Chemical Structure : TRPM4 inhibitor PBA

Catalog No.: PC-26527Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TRPM4 inhibitor PBA is a specific small molecule inhibitor of Ca2+-activated monovalent cation channel TRPM4 with IC50 of 339 nM using the fluorescence-based Na+-influx assay on HEK293 cells stably overexpressing hTRPM4.
TRPM4 inhibitor PBA inhibits TRPM4-mediated currents in whole-cell patch-clamp recordings from HCT116 cells with IC50 of 0.15 uM. TRPM4 inhibitor PBA inhibits both human and mouse TPRM4 but not human TRPM5.

Physicochemical Properties

M.Wt	359.76
Formula	C18H14ClNO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Chloro-2-(2-(3-(prop-2-yn-1-yloxy)phenoxy)acetamido)benzoic Acid

References

1. Gerber CE, et al. J Med Chem. 2026 Apr 13. doi: 10.1021/acs.jmedchem.5c02015.

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