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Chemical Structure : TRPM8 antagonist 14
Catalog No.: PC-35474Not For Human Use, Lab Use Only.
TRPM8 antagonist 14 is a potent, selective TRPM8 antagonist with IC50 of 0.2 nM in calcium influx assays, shows no activity on TRPV1.
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TRPM8 antagonist 14 is a potent, selective TRPM8 antagonist with IC50 of 0.2 nM in calcium influx assays, shows no activity on TRPV1; shows significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models.
| M.Wt | 398.506 | |
| Formula | C26H26N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bertamino A, et al. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545.
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