TRβ agonist TG68

Chemical Structure : TRβ agonist TG68

Catalog No.: PC-24497Not For Human Use, Lab Use Only.

TRβ agonist TG68 is a potent, selective agonist of thyroid hormone receptor-β (THRβ, TRβ), the prodrug of IS25 (TRβ, EC50=458 nM), promotes lipolysis through the activation of AMPK/ACC pathway.

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Biological Activity

TRβ agonist TG68 is a potent, selective agonist of thyroid hormone receptor-β (THRβ, TRβ), the prodrug of IS25 (TRβ, EC50=458 nM), promotes lipolysis through the activation of AMPK/ACC pathway.

Physicochemical Properties

M.Wt	369.46
Formula	C22H27NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-acetamido-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid

References

1. Perra A, et al. Cell Prolif. 2020 May;53(5):e12808.

2. Runfola M, et al. Eur J Med Chem. 2020 Feb 15;188:112006.

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