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Chemical Structure : TSHR ligand A35
Catalog No.: PC-21867Not For Human Use, Lab Use Only.
TSHR ligand A35 (NCATS-SM4420, NCGC00241808) is a specific Thyroid-stimulating hormone receptor (Thyrotropin receptor, TSHR) ligand, selectively activates TSHR-mediated cAMP accumulation in HEK-TSHR with EC50 of 240 nM, inhibits thyroid cancer (TC) cell proliferation and metastasis.
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TSHR ligand A35 (NCATS-SM4420, NCGC00241808) is a specific Thyroid-stimulating hormone receptor (Thyrotropin receptor, TSHR) inhibitor/ ligand, selectively activates TSHR-mediated cAMP accumulation in HEK-TSHR with EC50 of 240 nM, and inhibits thyroid cancer (TC) cell proliferation and metastasis.
A35 (NCATS-SM4420, NCGC00241808) does not inhibits proliferation of any cancer cells in the NCI-60 screen.
A35 (NCATS-SM4420, NCGC00241808) shows no detectable stimulatory activity at the closely related LH receptor (LHR) or FSH receptor (FSHR).
A35 (NCATS-SM4420, NCGC00241808) exertsan agonistic effect on the cAMP generation in normal thyrocytes with EC50 of 275 nM.
A35 (NCATS-SM4420, NCGC00241808) shows antiproliferative effects on thyroid cancer (TC) cells with IC50 values of 0.71 µM and 0.38 µM for MDA-T32 and MDA-T85, respectively.
A35 (NCATS-SM4420, NCGC00241808) inhibits pulmonary metastasis of MDA-T85F1 in mice.
A35 (NCATS-SM4420, NCGC00241808) is efficacious for CDX tumor growth inhibtion without decreases in mouse weights and liver function, reduces levels of Ki67 in the tumors and metastatic markers in lung tissues.
| M.Wt | 521.57 | |
| Formula | C31H27N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rhitajit Sarkar, et al. J Clin Endocrinol Metab. 2024 Feb 29:dgae114.
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