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Chemical Structure : TTA-A2
CAS No.: 953778-63-7
Catalog No.: PC-22153Not For Human Use, Lab Use Only.
TTA-A2 is a potent, selective, state-dependent T-type calcium channel antagonist with IC50 of 89 nM and 4100 nM in voltage clamp assays with -80-mV and -100-mV holding membrane potentials in HEK 293 cells heterologously expressing human CaV3.1, respectively.
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
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TTA-A2 is a potent, selective, state-dependent T-type calcium channel antagonist with IC50 of 89 nM and 4100 nM in voltage clamp assays with -80-mV and -100-mV holding membrane potentials in HEK 293 cells heterologously expressing human CaV3.1, respectively.
TTA-A2 displays no significant activities against L-, N-, P/Q-, and R-type calcium channels.
TTA-A2 decreases inactive phase food intake and accentuates diurnal rhythms in core temperature and activity during HFD.
TTA-A2 reduces body weight and improves body composition in diet-induced obese rats.
| M.Wt | 378.40 | |
| Formula | C20H21F3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Cyclopropyl-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]benzeneacetamide |
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1. Uebele VN, et al. J Clin Invest. 2009 Jun;119(6):1659-67.
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