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Chemical Structure : TTA-Q6
CAS No.: 910484-28-5
Catalog No.: PC-21849Not For Human Use, Lab Use Only.
TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively.
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|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $268 | In stock | |
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| 100 mg | Get quote |
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TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively.
TTA-Q6 is a potent T-type Ca(2+) channel antagonist with minimized PXR activation.
TTA-Q6 suppresses seizure frequency in a rat model of absence epilepsy and shows significant alterations of sleep architecture after oral dosing to rats.
| M.Wt | 405.81 | |
| Formula | C20H15ClF3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-4-(6-chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile |
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1. Schlegel KA, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5147-52.
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