TUG-2181 | GPR84 antagonist | Probechem Biochemicals

Chemical Structure : TUG-2181

TUG-2181 (TUG2181)

Catalog No.: PC-24433Not For Human Use, Lab Use Only.

TUG-2181 is a potent, selective antagonist of GPR84 with pIC50 of 7.66 and 5.89 for hGPR84 and mGPR84 respecitvely in cAMP assays.

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Biological Activity

TUG-2181 is a potent, selective antagonist of GPR84 with pIC50 of 7.66 and 5.89 for hGPR84 and mGPR84 respecitvely in cAMP assays.
TUG-2181 does not inhibit free fatty acid receptors FFA1, FFA2, FFA3, and FFA4 at 10 uM
TUG-2181 inhibits embelin-induced respiratory burst and IL-8 release in human neutrophils.

Physicochemical Properties

M.Wt	357.45
Formula	C21H27NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-Ethoxyphenethyl)-6-((tetrahydro-2H-pyran-2-yl)methoxy)pyridin-4-ol

References

1. Ieremias L, et al. J Med Chem. 2025 Apr 4. doi: 10.1021/acs.jmedchem.4c02335.

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TUG-2181 (TUG2181)

Biological Activity

Physicochemical Properties

References

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