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Chemical Structure : TVB-2640
CAS No.: 1399177-37-7
Catalog No.: PC-72346Not For Human Use, Lab Use Only.
TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM, inhibits lipogenesis with therapeutic potential against NAFLD, nonalcoholic steatohepatitis, and KRAS MUT solid tumors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM, inhibits lipogenesis with therapeutic potential against NAFLD, nonalcoholic steatohepatitis, and KRAS MUT solid tumors.
| M.Wt | 439.563 | |
| Formula | C27H29N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
>500 mM in DMSO (>220 mg/mL) |
|
| Chemical Name/SMILES |
4-(1-(4-Cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl)piperidin-4-yl)benzonitrile |
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1. Syed-Abdul MM, et al. Hepatology. 2020 Jul;72(1):103-118.
2. Singh S, et al. Mini Rev Med Chem. 2020;20(18):1820-1837.
3. Loomba R, et al. Gastroenterology. 2021 Nov;161(5):1475-1486.
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