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Chemical Structure : TVB3664
CAS No.: 2097262-58-1
Catalog No.: PC-72780Not For Human Use, Lab Use Only.
TVB3664 is a potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor with IC50 of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
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| 100 mg | Get quote |
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TVB3664 is a potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor with IC50 of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively.
TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression.
Anti-tumor effect of TVB-3664 was associated with a significant decrease in a pool of adenine nucleotides and alterations in lipid composition including a significant reduction in fatty acids and phospholipids and an increase in lactosylceramide and sphingomyelin in PDXs sensitive to FASN inhibition.
| M.Wt | 468.47 | |
| Formula | C25H23F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(1-(5-(4-(methoxymethyl)-2-(trifluoromethyl)-1H-imidazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile |
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1. Zaytseva YY, et al. Oncotarget. 2018 May 15;9(37):24787-24800.
2. Heuer TS, et al. EBioMedicine. 2017 Feb;16:51-62.
3. Wang H, et al. Hepatology. 2022 Jan 25.
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