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Chemical Structure : TXS-8
Catalog No.: PC-47062Not For Human Use, Lab Use Only.
TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome.
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TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome.
TXS-8 showed binding affinity towards Rpn-6 in biochemical and cell-based assays.
TXS-8 was also preferentially cytotoxic to cancer cell lines that require significant 26S proteasome activity for survival (MM.1R and Ramos B-cells, IC50=14 uM).
TXS-8 exhibited no appreciable binding against other 19S RP subunit, including Rpn-13. a useful tool to further elucidate the role of Rpn-6.
Rpn-6 is a proteasome-associated protein that makes critical contacts with the 19S regulatory particle (19S RP)and the 20S core particle (20S CP) of the proteasome.
| M.Wt | 572.750 | |
| Formula | C34H44N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tian W, et al. ACS Chem Biol. 2020 Feb 21;15(2):554-561.
2. Tian W, et al. Chembiochem. 2021 Jun 2;22(11):1961-1965.
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