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Chemical Structure : TY-52156
CAS No.: 934369-14-9
Catalog No.: PC-21209Not For Human Use, Lab Use Only.
TY-52156 is a potent, selective S1P3 receptor antagonist with Ki of 110 nM.
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|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
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TY-52156 is a potent, selective S1P3 receptor antagonist with Ki of 110 nM.
TY-52156 preferentially inhibited the S1P-induced increase in [Ca2]i in S1P3-CHO rather than S1P1-, S1P2-CHO, and S1P4-Chem.
TY-52156 inhibited both the S1P-induced increase in [Ca(2+)](i) and Rho activation in human coronary artery smooth muscle cells.
TY-52156 inhibited FTY-720-induced S1P(3) receptor-mediated bradycardia in vivo.
| M.Wt | 364.27 | |
| Formula | C18H19Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl- 2-butanone |
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1. Murakami A, et al. Mol Pharmacol. 2010 Apr;77(4):704-13.
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