Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Takinib
CAS No.: 1111556-37-6
Catalog No.: PC-61197Not For Human Use, Lab Use Only.
Takinib is a potent, selective TAK1 inhibitor with IC50 of 9.5 nM, selectively induces apoptosis following TNF-a stimulation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Takinib is a potent, selective TAK1 inhibitor with IC50 of 9.5 nM, selectively induces apoptosis following TNF-a stimulation.
Takinib weakly inhibits IRAK4, IRAK1, GCK, CLK2, and MINK1 with IC50 of 120-430 nM against the MRC Dundee kinase panel.
Takinib does not inhibit any of the MAP2Ks or MAP3Ks family members.
Takinib inhibits phosphorylation of IKK, MAPK 8/9, and c-Jun, induces apoptosis in RA fibroblast-like synoviocytes and reduces IL-6 secretion, induces TNF-α-dependent cell death in rheumatoid arthritis and breast cancer cells.
| M.Wt | 322.368 | |
| Formula | C18H18N4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,3-Benzenedicarboxamide, N1-(1-propyl-1H-benzimidazol-2-yl)- |
|
1. Totzke J, et al. Cell Chem Biol. 2017 Aug 17;24(8):1029-1039.e7.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
