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Chemical Structure : Talnetant
CAS No.: 174636-32-9
Catalog No.: PC-21365Not For Human Use, Lab Use Only.
Talnetant (SB223412) is a potent, selective, competitive and brain-permeable neurokinin-3 receptor (NK3R) antagonist with Ki of 1.4 nM in hNK-3-CHO cells.
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|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
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Talnetant (SB223412) is a potent, selective, competitive and brain-permeable neurokinin-3 receptor (NK3R) antagonist with Ki of 1.4 nM in hNK-3-CHO cells.
Talnetant (SB223412) displays >100-fold selectivity for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant (SB223412) reduces the accumulation of NKB-induced IP in U-2OS cells expressing the human NK3 receptor.
Talnetant (SB223412) inhibit the miosis induced by senktide in a dose-dependent manner with an ED50 of 0.44mg/kg in conscious rabbits.
Talnetant (SB223412) significantly attenuate senktide-induced "wet dog wagging" behavior in a dose-dependent manner.
Talnetant (SB223412) significantly increase extracellular dopamine and norepinephrine in the medial prefrontal cortex and reduce haloperidol-induced increases in dopamine levels in the vomeronasal nucleus of freely moving guinea pigs.
| M.Wt | 382.46 | |
| Formula | C25H22N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide |
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1. Giardina GA, et al. J Med Chem. 1999 Mar 25;42(6):1053.
2. Dawson LA, et al. Neuropsychopharmacology. 2008 Jun;33(7):1642-52.
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