Catalog No.: PC-28063Not For Human Use, Lab Use Only.
Tanshinone I is a natural compound isolated from the roots of Salvia miltiorrhiza Bunge with antagonist activity at GABAA receptors, inhibits type IIA human recombinant sPLA2 (IC50=11 uM) and rabbit recombinant cPLA2 (IC50=82 uM), also is a Syk inhibitor (IC50=1.64 uM) and exhibits anti-mast cell degranulation activity in vitro (IC50=2.76 uM).
Tanshinone I is a natural compound isolated from the roots of Salvia miltiorrhiza Bunge with antagonist activity at GABAA receptors, inhibits type IIA human recombinant sPLA2 (IC50=11 uM) and rabbit recombinant cPLA2 (IC50=82 uM), also is a Syk inhibitor (IC50=1.64 uM) and exhibits anti-mast cell degranulation activity in vitro (IC50=2.76 uM).
Tanshinone I ameliorates the learning and memory impairments induced by diazepam and MK-801 through activation of ERK signalling.
Tanshinone I also inhibits SARS-CoV-2 PLpro with IC50 of 2.21 uM.
Tanshinone I inhibits PGE(2) formation from LPS-induced RAW macrophages with IC50 of 38 uM.
Tanshinone I shows in vivo antiinflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis.
Physicochemical Properties
M.Wt
276.29
Formula
C18H12O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione
References
1. Kim DH, et al. Br J Pharmacol. 2009 Oct;158(4):1131-42.
2. Zhao Y, et al. Protein Cell. 2021 Nov;12(11):877-888.
3. Wang X, et al. Molecules. 2018 Nov 28;23(12):3114.
4. Kim SY, et al. Phytother Res. 2002 Nov;16(7):616-20.
