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Chemical Structure : Taranabant
CAS No.: 701977-09-5
Catalog No.: PC-42063Not For Human Use, Lab Use Only.
Taranabant (MK-0364) is a potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
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Taranabant (MK-0364) is a potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM.
Taranabant displays >1000-fold selectivity over CB2R (Ki=170 nM), AT1R, NK2R, A3R, MT1R, D1R, etc.
Taranabant dose-dependently inhibits food intake and weight gain in diet-induced obese (DIO) rats with an acute minimum effective dose of 1 mg/kg and has good pharmacokinetic.
| M.Wt | 515.9545 | |
| Formula | C27H25ClF3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
Propanamide, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]- |
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1. Armstrong HE, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2184-7.
2. Fong TM, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1013-22.
3. Addy C, et al. Cell Metab. 2008 Jan;7(1):68-78.
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