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Tecalcet hydrochloride

Chemical Structure : Tecalcet hydrochloride

CAS No.: 177172-49-5

Tecalcet hydrochloride (R-568;NPS R-568;KRN-568;NPS-568)

Catalog No.: PC-62908Not For Human Use, Lab Use Only.

Tecalcet (R-568; NPS R-568; KRN-568; NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
Tecalcet (R-568) potentiates the effects of extracellular Ca2+ on [Ca2+]i and PTH secretion without effect in the absence of extracellular Ca2+, does not affect responses elicited by the homologous mGluRs; prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism.

Physicochemical Properties

M.Wt 340.288
Formula C18H23Cl2NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine, monohydrochloride

References

1. Wada M, et al. J Clin Invest. 1997 Dec 15;100(12):2977-83., et al.

2. Nemeth EF, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4040-5.

3. Wada M, et al. Kidney Int. 2000 Jan;57(1):50-8.

4. Hammerland LG, et al. Mol Pharmacol. 1998 Jun;53(6):1083-8.

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