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Chemical Structure : Tetrazole compound D2
Catalog No.: PC-22136Not For Human Use, Lab Use Only.
Tetrazole compound D2 is a novel antifungal inhibitor with MIC values of <0.008, <0.008, and 2 μg/mL against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, respectively.
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Tetrazole compound D2 is a novel antifungal inhibitor with MIC values of <0.008, <0.008, and 2 μg/mL against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, respectively.
Tetrazole compound D2 also exhibits potent activity against fluconazole-resistant C. auris isolates with MIC value of <0.125-1 ug/mL. Tetrazole compound D2 showed better in vivo efficacy than albaconazole at reducing fungal burden and extending the survival of C. albicans-infected mice.
| M.Wt | 431.83 | |
| Formula | C20H16ClF2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ni T, et al. J Med Chem. 2024 Apr 10. doi: 10.1021/acs.jmedchem.3c02188.
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