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Chemical Structure : Thailanstatin D
Catalog No.: PC-73161Not For Human Use, Lab Use Only.
Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities.
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Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities.
Thailanstatin D inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and Thailanstatin D preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site.
Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis.
Thailanstatins are attractive cytotoxin agent for ADC design.
| M.Wt | 519.63 | |
| Formula | C28H41NO8 | |
| Appearance | Solid | |
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1. Kulkarni C, et al. Bioconjug Chem. 2017 Apr 19;28(4):1041-1047.
2. Puthenveetil S, et al. PLoS One. 2017 May 30;12(5):e0178452.
3. Wang B, et al. Int J Cancer. 2017 Nov 15;141(10):2121-2130.
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