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Thanatin

Chemical Structure : Thanatin

CAS No.: 214542-43-5

Thanatin

Catalog No.: PC-28582Not For Human Use, Lab Use Only.

Thanatin is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.

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Biological Activity

Thanatin is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.

Physicochemical Properties

M.Wt 2433.92
Formula C103H177N35O27S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met (Disulfide bridge:Cys11-Cys18)

References

1. Fehlbaum P, et al. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-5.

2. Mandard N, et al. Eur J Biochem. 1998 Sep 1;256(2):404-10.

3. Javadmanesh A, et al. Sci Rep. 2021 May 25;11(1):10890.

4. Ma B, et al. Nat Commun. 2019 Aug 6;10(1):3517.

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