Catalog No.: PC-28583Not For Human Use, Lab Use Only.
Thanatin TFA is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.
Thanatin TFA is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.
Physicochemical Properties
M.Wt
2433.92 (free base)
Formula
C103H177N35O27S3.xC2HF3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met (Disulfide bridge:Cys11-Cys18) TFA salt
References
1. Fehlbaum P, et al. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-5.
2. Mandard N, et al. Eur J Biochem. 1998 Sep 1;256(2):404-10.
3. Javadmanesh A, et al. Sci Rep. 2021 May 25;11(1):10890.
4. Ma B, et al. Nat Commun. 2019 Aug 6;10(1):3517.
