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Chemical Structure : Thapsigargin
CAS No.: 67526-95-8
Catalog No.: PC-60883Not For Human Use, Lab Use Only.
Thapsigargin (G202) is a potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $568 | In stock | |
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| 100 mg | Get quote |
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Thapsigargin (G202) is a potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
Thapsigargin inhibits the Ca2+ ATPase of rat liver ER about 100% at 170 nM, but no inhibition for skeletal muscle SR.
Thapsigargin increases the concentration of cytosolic free Ca2+ in sensitive cells by an acute and highly specific arrest of the endoplasmic reticulum Ca2+ pump.
| M.Wt | 650.76 | |
| Formula | C34H50O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate |
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1. Davidson GA, et al. J Biol Chem. 1995 May 19;270(20):11731-4.
2. Thastrup O, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70.
3. Yu M, et al. J Biol Chem. 1998 Feb 6;273(6):3542-6.
4. Panagaki T, et al. Sci Rep. 2017 Nov 23;7(1):16158.
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