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Thiazovivin

Chemical Structure : Thiazovivin

CAS No.: 1226056-71-8

Thiazovivin

Catalog No.: PC-43437Not For Human Use, Lab Use Only.

Thiazovivin is a small molecule inhibitor of ROCK, dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Thiazovivin is a small molecule inhibitor of ROCK, dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts; dramatically improves the survival of hESCs upon trypsinization, addition of Thiazovivin to cocktail of SB431542 and PD0325901 also vastly improves the survival of iPSCs after splitting by trypsinization; induces porcine embryonic fibroblasts into adipocytes.

Physicochemical Properties

M.Wt
Formula C15H13N5OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

4-Thiazolecarboxamide, N-(phenylmethyl)-2-(4-pyrimidinylamino)-

References

1. Lin T, et al. Nat Methods. 2009 Nov;6(11):805-8.

2. Zhu J, et al. Cell Reprogram. 2012 Apr;14(2):99-105.

3. Wang F, et al. Gastroenterology. 2013 Aug;145(2):383-95.e1-21.

4. Mohseni R, et al. Cell Biol Int. 2015 May;39(5):515-8.

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