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Chemical Structure : Thr-Asp-F-amidine
Catalog No.: PC-62360Not For Human Use, Lab Use Only.
Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3.
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Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3.
TDFA is active in cells and can be used to inhibit PAD4 activity in cellulo.
| M.Wt | 448.452 | |
| Formula | C17H29FN6O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jones JE, et al. ACS Chem Biol. 2012 Jan 20;7(1):160-5.
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