Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Tim-3 inhibitor ML-T7
Catalog No.: PC-21328Not For Human Use, Lab Use Only.
Tim-3 inhibitor ML-T7 is a potent small molecule inhibitor of T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), binds to Tim-3 disrupts the interaction of Tim-3 with PtdSer and CEACAM1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Tim-3 inhibitor ML-T7 is a potent small molecule inhibitor of T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), binds to Tim-3 disrupts the interaction of Tim-3 with PtdSer and CEACAM1.
ML-T7 targets the FG-CC' cleft of Tim-3, a highly conserved binding site of phosphatidylserine (PtdSer) and carcinoembryonic antigen–related cell adhesion molecule 1 (CEACAM1).
ML-T7 binds to hTim-3 and mTim-3 with Kd (dissociation constant) values of 6.98 and 7.40 μM, respectively.
ML-T7 blocks hTim-3 binding to CEACAM1-overexpressing Jurkat cells in a concentration-dependent manner and directly disrupts CEACAM1 binding to hTim-3 in SPR assay.
ML-T7 does not block Tim-3/galectin-9 interaction.
ML-T7 enhances TCR/STAT5 signaling and promotes CD8+ T cell antitumor activity through Tim-3.
ML-T7 directly potentiates the survival and prevents exhaustion of CD8+ cytotoxic T lymphocytes (CTLs), potentiates functions of DCs through both Tim-3 and Tim-4.
ML-T7 (50 mg/kg) exerts antitumor activity in preclinical syngeneic mouse models and humanized mice, potentiates anti–PD-1 therapy in vivo.
| M.Wt | 506.34 | |
| Formula | C27H17Cl2NO5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Ma S, et al. Sci Transl Med. 2023 Nov 15;15(722):eadg6752.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
